Centurial educational institution, St. Francis Xavier’s Girls’ School & College is one of the famous institutions of Bangladesh. She has been continuing her journey though there are so many obstacles. The institution was founded by RMDM sisters to enlighten the oppressive girls and women. This institution does not pay importance only for bookish knowledge, but encourage students practicing morality, mental and social development and to be patriotic in future. In 1882, Dom Gregory D. Grud O.S.B, the provincial of Holy Cross Congregation established St. Gregory’s School for the Boys and Girls to spread the light of education in Southern part of Dhaka. But for the shortage of money the School was closed after few years. Then some European and Anglo Indian parents established another school for Girls and Boys. The school was founded on the bank on the river Buriganga, near the Wize Ghat. There were only few Catholic students and most of the other students were non-Catholic. At first, an Alian priest and after that a Baptist priest was appointed for religion teacher of the Catholic students. But father Francis Boris C.S.C, a catholic priest protested and suggested Mr.  And Mrs. Vages to teach religion to the catholic students. In 1889, Father Francis C.S.C again started St. Gregory’s School. At that time only the European and Anglo – Indian students studied at the institution. Gradually some catholic students from Mr. and Mrs. Vage’s school admitted at St. Gregory’s School. After a long broke – up again some sisters of the Holy Cross Congregation returned to the East Bengal in 1889. Bishop of Dhaka requested them to take the responsibilities of St. Gregory’s School. After taking the responsibility of the administration by Holy Cross sisters, it became one of the famous institutions of East Bengal within few years. But unfortunately, in 1896 sisters of the Holy Cross Congregation left the East Bengal and the administration was taken by salesian sisters. In 1912 Salesian sisters also left the responsibility of the St. Gregory’s School. At last, in 1912 Bishops Fredrick Linnborn C.S.C proposed R.M.D.M. sisters to take the responsibilities of the school. At that time sister Mary D’ Jesus Adolescent R.M.D.M. sister  Mary St. Irene R.M.D.M, sister Mary St. Bertille R.M.D.M,  sister Mary St. Antheline R.M.D.M, and sister Mary St. Denise took the responsibilities of the institution, but they proposed to the Bishop that they would take responsibilities only for the female students. Bishop Fredrick Linnborn C.S.C agreed to their proposal. At last, RMDM sisters started St. Francis Xavier’s Girls & School as an English Medium School only for the female students. European and Euro – Asian female students from St. Gregory’s School were admitted in St. Francis Xavier’s Girls & School. It should be mentioned here, that the institution was named in 1912 in memory of great St. Francis Xavier. At the very beginning of the institution there were only ten teachers and sixty pupils. Mother Mary RMDM was appointed as Headmistress of St. Francis Xavier’s Girls’ School for the first time. Before the division of India and Pakistan the students had to go to Kolkata to appear for the Examination of Higher-Grade Certificate. In 1947, after division India and Pakistan for the Cambridge School Certificates Examination, the institution was led under Cambridge University England by the confirmation of Pakistani Director of Public Instructions. At that time, though it was an English Medium School some students could study in Bangla also. The students, who were studied in Bangla they stayed at school Hostel and they could write Public Matriculation Examination from Collegiate School. Male students were allowed to study to class two in English Medium School. After the liberation war of Bangladesh, March 1, 1972, under the direction by Bangladesh Government, it was changed as a Bangla Medium School. But on May 17, 1972, Soyad Rezaul Hayad, secretary of the education ministry, sent a letter to confirm that the institution could continue as an English Medium School. After that, the school was divided into two parts —- St. Francis Xavier’s Green Herald International School at Mohammadpur and St. Francis Xavier's Girls' School at Luxmibazar.   Sister Mary Zoe R.M.D.M was appointed the Headmistress for the Bangla Medium School for the first time. In 1973 Sister Mary Paulina RMDM was appointed as a Headmistress. Her dedication and hard labour brought new life to the institution after the Liberation War. She served the institution as a Headmistress for thirteen years. It was only a Junior Girls School up to 1978. But on January 1, 1979 the institution got pessimism to open class Nine & Ten permanently and enlisted for public S.S.C Examination for the first time in 1981. In 1986 sister Lourdes Mary RMDM was appointed as a Headmistress. She worked hard to build up the new school building. Arch Bishop Micheal Rozario inaugurated the new building on January 28,1993. On July 20, 2006 Sister Renu Maria Palma, took the responsibility of the institution as a Headmistress and continued up to October 12, 2014.  The institution had got another Principal Sister Mary Palma RMDM who was appointed on October 13, 2014. At present, Sister Nilu Mree RMDM who has been appointed as a principal on June 12, 2020. But it was very challenging because of Pandemic at that time and she got affected with corona. With the blessings of God, she came round and left no stone unturned to run the institution. During the pandemic, Sr. Nilu Mree RNDM, the principal of this institute, was tasked with the challenging responsibility of balancing the students’ academic, social, emotional, and physical needs in response to the health concerns, expectations, and needs of teachers, school authorities, parents, and local stakeholders. Our vice-principal is Sister Gracie Gomes, RMDM. College Section: It is very remarkable that the institution has started its new journey with college section in 2017 with 51 students and 11 lecturers. The name has been changed and the new name is — "St. Francis Xavier’s Girls’ School & ollege." Sister Renu Maria Palma, RMDM took the first initiative to upgrade the institution as a college section. It is notable that Sister Mary Palma RMDM, worked hard to upgrade this institution as a college section. At present the institution runs very well.